Three-dimensional system enabling the maintenance and directed differentiation of pluripotent stem cells under defined conditions

The development of in vitro models for the maintenance and differentiation of pluripotent stem cells (PSCs) is an active area of stem cell research. The strategies used so far are based mainly on two-dimensional (2D) cultures, in which cellular phenotypes are regulated by soluble factors. We show th...

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Bibliographic Details
Published in:Sci Adv
Main Authors: Zujur, Denise, Kanke, Kosuke, Lichtler, Alexander C., Hojo, Hironori, Chung, Ung-il, Ohba, Shinsuke
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2017
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5429032/
https://ncbi.nlm.nih.gov/pubmed/28508073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1602875
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