Stepwise strategy for generating osteoblasts from human pluripotent stem cells under fully defined xeno-free conditions with small-molecule inducers

Clinically relevant human induced pluripotent stem cell (hiPSC) derivatives require efficient protocols to differentiate hiPSCs into specific lineages. Here we developed a fully defined xeno-free strategy to direct hiPSCs toward osteoblasts within 21 days. The strategy successfully achieved the oste...

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Détails bibliographiques
Publié dans:Regen Ther
Auteurs principaux: Zujur, Denise, Kanke, Kosuke, Onodera, Shoko, Tani, Shoichiro, Lai, Jenny, Azuma, Toshifumi, Xin, Xiaonan, Lichtler, Alexander C., Rowe, David W., Saito, Taku, Tanaka, Sakae, Masaki, Hideki, Nakauchi, Hiromitsu, Chung, Ung-il, Hojo, Hironori, Ohba, Shinsuke
Format: Artigo
Langue:Inglês
Publié: Japanese Society for Regenerative Medicine 2020
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965656/
https://ncbi.nlm.nih.gov/pubmed/31988991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.reth.2019.12.010
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