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Achieving cell penetration with distance-matching cysteine cross-linkers: a facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx()

We report the design of bisarylmethylene bromides as a new class of rigid, distance-matching cysteine cross-linkers. By cross-linking a peptide dual inhibitor of Mdm2/Mdmx containing cysteines at i,i+7 positions, dramatic enhancement in cell permeability was achieved, along with increased helicity a...

詳細記述

保存先:
書誌詳細
出版年:Chem Commun (Camb)
主要な著者: Muppidi, Avinash, Wang, Zhiyong, Li, Xiaolong, Chen, Jiandong, Lin, Qing
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5428881/
https://ncbi.nlm.nih.gov/pubmed/21773579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c1cc13320a
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