Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors

Identification of driver genes contributes to the understanding of cancer etiology and is imperative for the development of individualized therapies. Gene amplification is a major event in oncogenesis. Driver genes with tumor-specific amplification-dependent overexpression can be therapeutic targets...

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Udgivet i:Sci Rep
Main Authors: Ohshima, Keiichi, Hatakeyama, Keiichi, Nagashima, Takeshi, Watanabe, Yuko, Kanto, Kaori, Doi, Yuki, Ide, Tomomi, Shimoda, Yuji, Tanabe, Tomoe, Ohnami, Sumiko, Ohnami, Shumpei, Serizawa, Masakuni, Maruyama, Koji, Akiyama, Yasuto, Urakami, Kenichi, Kusuhara, Masatoshi, Mochizuki, Tohru, Yamaguchi, Ken
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5428069/
https://ncbi.nlm.nih.gov/pubmed/28377632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00219-3
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