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Cellular and cell-free studies of catalytic DNA cleavage by ruthenium polypyridyl complexes containing redox-active intercalating ligands
The ruthenium(ii) polypyridyl complexes (RPCs), [(phen)(2)Ru(tatpp)](2+) (3(2+)) and [(phen)(2)Ru(tatpp)Ru(phen)(2)](4+) (4(4+)) are shown to cleave DNA in cell-free studies in the presence of a mild reducing agent, i.e. glutathione (GSH), in a manner that is enhanced upon lowering the [O(2)]. React...
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| Publicado en: | Chem Sci |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Royal Society of Chemistry
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5428021/ https://ncbi.nlm.nih.gov/pubmed/28553531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc04094b |
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