Disruption of microtubule function in cultured human cells by a cytotoxic ruthenium(ii) polypyridyl complex

Treatment of malignant and non-malignant cultured human cell lines with a cytotoxic IC(50) dose of ∼2 μM tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(ii) chloride (RPC2) retards or arrests microtubule motion as tracked by visualizing fluorescently-tagged microtubule plus end-tracking proteins. Im...

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Udgivet i:Chem Sci
Main Authors: Alatrash, Nagham, Issa, Faiza H., Bawazir, Nada S., West, Savannah J., Van Manen-Brush, Kathleen E., Shelor, Charles P., Dayoub, Adam S., Myers, Kenneth A., Janetopoulos, Christopher, Lewis, Edwin A., MacDonnell, Frederick M.
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society of Chemistry 2019
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8133002/
https://ncbi.nlm.nih.gov/pubmed/34040721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc05671h
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