A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition

Ruthenium(II) polypyridyl complexes can intercalate DNA with high affinity and prevent cell proliferation; however, the direct impact of ruthenium-based intercalation on cellular DNA replication remains unknown. Here we show the multi-intercalator [Ru(dppz)(2)(PIP)](2+) (dppz = dipyridophenazine, PI...

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Vydáno v:Sci Rep
Hlavní autoři: Gill, Martin R., Harun, Siti Norain, Halder, Swagata, Boghozian, Ramon A., Ramadan, Kristijan, Ahmad, Haslina, Vallis, Katherine A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4997316/
https://ncbi.nlm.nih.gov/pubmed/27558808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31973
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