A three-in-one-bullet for oesophageal cancer: replication fork collapse, spindle attachment failure and enhanced radiosensitivity generated by a ruthenium(ii) metallo-intercalator

Substitutionally inert ruthenium(ii) polypyridyl complexes have been developed as DNA intercalating agents yet cellular DNA damage responses to this binding modality are largely unexplored. Here, we show the nuclear-targeting complex [Ru(phen)(2)(tpphz)](2+) (phen = 1,10-phenanthroline, tpphz = tetr...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Gill, Martin R., Jarman, Paul J., Halder, Swagata, Walker, Michael G., Saeed, Hiwa K., Thomas, Jim A., Smythe, Carl, Ramadan, Kristijan, Vallis, Katherine A.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870190/
https://ncbi.nlm.nih.gov/pubmed/29629151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc03712k
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