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Preferential DNA Cleavage under Anaerobic Conditions by a DNA Binding Ruthenium Dimer
[Image: see text] In the absence of O(2), the cationic complex, [(phen)(2)Ru(tatpp)Ru(phen)(2)](4+) (P(4+)), undergoes in situ reduction by glutathione (GSH) to form a species that induces DNA cleavage. Exposure to air strongly attenuates the cleavage activity, even in the presence of a large excess...
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| Huvudupphovsmän: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2007
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2525620/ https://ncbi.nlm.nih.gov/pubmed/17388584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ic0619714 |
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