The m(6)A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-Like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program

The dynamic and reversible N(6)-methyladenosine (m(6)A) RNA modification installed and erased by N(6)-methyltransferases and demethylases regulates gene expression and cell fate. We show that the m(6)A demethylase ALKBH5 is highly expressed in glioblastoma stem-like cells (GSCs). Silencing ALKBH5 su...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Zhang, Sicong, Zhao, Boxuan Simen, Zhou, Aidong, Lin, Kangyu, Zheng, Shaoping, Lu, Zhike, Chen, Yaohui, Sulman, Erik P., Xie, Keping, Bögler, Oliver, Majumder, Sadhan, He, Chuan, Huang, Suyun
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427719/
https://ncbi.nlm.nih.gov/pubmed/28344040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.02.013
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