A phase I trial of the Hedgehog inhibitor, sonidegib (LDE225), in combination with etoposide and cisplatin for the initial treatment of extensive stage small cell lung cancer

OBJECTIVES: The Hedgehog pathway has been implicated in small cell lung cancer (SCLC) tumor initiation and progression. Pharmacologic blockade of the key Hedgehog regulator, Smoothened, may inhibit these processes. We performed a phase I study to determine the maximum tolerated dose (MTD) of sonideg...

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Gepubliceerd in:Lung Cancer
Hoofdauteurs: Pietanza, M. Catherine, Litvak, Anya M., Varghese, Anna M., Krug, Lee M., Fleisher, Martin, Teitcher, Jerrold B., Holodny, Andrei I., Sima, Cami S., Woo, Kaitlin M., Ng, Kenneth K., Won, Helen H., Berger, Michael F., Kris, Mark G., Rudin, Charles M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427482/
https://ncbi.nlm.nih.gov/pubmed/27565909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2016.04.014
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