PTEN mediates Notch-dependent stalk cell arrest in angiogenesis

Coordinated activity of VEGF and Notch signals guides the endothelial cell (EC) specification into tip and stalk cells during angiogenesis. Notch activation in stalk cells leads to proliferation arrest via an unknown mechanism. By using gain- and loss-of-function gene-targeting approaches, here we s...

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Publicado en:Nat Commun
Main Authors: Serra, Helena, Chivite, Iñigo, Angulo-Urarte, Ana, Soler, Adriana, Sutherland, James D., Arruabarrena-Aristorena, Amaia, Ragab, Anan, Lim, Radiance, Malumbres, Marcos, Fruttiger, Marcus, Potente, Michael, Serrano, Manuel, Fabra, Àngels, Viñals, Francesc, Casanovas, Oriol, Pandolfi, Pier Paolo, Bigas, Anna, Carracedo, Arkaitz, Gerhardt, Holger, Graupera, Mariona
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5426521/
https://ncbi.nlm.nih.gov/pubmed/26228240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8935
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