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Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis

Understanding the direct, tumor cell–intrinsic effects of PI 3-kinase (PI3K) has been a key focus of research to date. Here, we report that cancer cell–extrinsic PI3K activity, mediated by the p110α isoform of PI3K, contributes in an unexpected way to tumor angiogenesis. In syngeneic mouse models, i...

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Main Authors: Soler, Adriana, Serra, Helena, Pearce, Wayne, Angulo, Ana, Guillermet-Guibert, Julie, Friedman, Lori S., Viñals, Francesc, Gerhardt, Holger, Casanovas, Oriol, Graupera, Mariona, Vanhaesebroeck, Bart
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782054/
https://ncbi.nlm.nih.gov/pubmed/24043760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121571
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