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Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis
Understanding the direct, tumor cell–intrinsic effects of PI 3-kinase (PI3K) has been a key focus of research to date. Here, we report that cancer cell–extrinsic PI3K activity, mediated by the p110α isoform of PI3K, contributes in an unexpected way to tumor angiogenesis. In syngeneic mouse models, i...
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| Main Authors: | , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Rockefeller University Press
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3782054/ https://ncbi.nlm.nih.gov/pubmed/24043760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121571 |
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