Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis

Understanding the direct, tumor cell–intrinsic effects of PI 3-kinase (PI3K) has been a key focus of research to date. Here, we report that cancer cell–extrinsic PI3K activity, mediated by the p110α isoform of PI3K, contributes in an unexpected way to tumor angiogenesis. In syngeneic mouse models, i...

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Detaylı Bibliyografya
Asıl Yazarlar: Soler, Adriana, Serra, Helena, Pearce, Wayne, Angulo, Ana, Guillermet-Guibert, Julie, Friedman, Lori S., Viñals, Francesc, Gerhardt, Holger, Casanovas, Oriol, Graupera, Mariona, Vanhaesebroeck, Bart
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2013
Konular:
Brief Definitive Report
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782054/
https://ncbi.nlm.nih.gov/pubmed/24043760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121571
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