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Disease–Drug Interaction of Sarilumab and Simvastatin in Patients with Rheumatoid Arthritis
INTRODUCTION: Elevated interleukin (IL)-6 occurs in patients with active rheumatoid arthritis (RA), which has been shown to lead to a decrease in cytochrome P450 (CYP) enzyme activity and alterations in drug concentrations metabolized by CYP. IL-6 signaling blockade by IL-6 receptor (IL-6R) antagoni...
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| Publicado no: | Clin Pharmacokinet |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5425488/ https://ncbi.nlm.nih.gov/pubmed/27722854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-016-0462-8 |
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