Disease–Drug Interaction of Sarilumab and Simvastatin in Patients with Rheumatoid Arthritis

INTRODUCTION: Elevated interleukin (IL)-6 occurs in patients with active rheumatoid arthritis (RA), which has been shown to lead to a decrease in cytochrome P450 (CYP) enzyme activity and alterations in drug concentrations metabolized by CYP. IL-6 signaling blockade by IL-6 receptor (IL-6R) antagoni...

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Udgivet i:Clin Pharmacokinet
Main Authors: Lee, Eun Bong, Daskalakis, Nikki, Xu, Christine, Paccaly, Anne, Miller, Barry, Fleischmann, Roy, Bodrug, Inga, Kivitz, Alan
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2016
Fag:
Original Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5425488/
https://ncbi.nlm.nih.gov/pubmed/27722854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-016-0462-8
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