Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation

Somatic hypermutation (SHM) plays a critical role in the maturation of antibodies, optimizing recognition initiated by recombination of V(D)J genes. Previous studies have shown that the propensity to mutate is modulated by the context of surrounding nucleotides and that SHM machinery generates biase...

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Publicat a:Front Immunol
Autors principals: Sheng, Zizhang, Schramm, Chaim A., Kong, Rui, Mullikin, James C., Mascola, John R., Kwong, Peter D., Shapiro, Lawrence
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424261/
https://ncbi.nlm.nih.gov/pubmed/28539926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00537
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