Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation

Somatic hypermutation (SHM) plays a critical role in the maturation of antibodies, optimizing recognition initiated by recombination of V(D)J genes. Previous studies have shown that the propensity to mutate is modulated by the context of surrounding nucleotides and that SHM machinery generates biase...

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Udgivet i:Front Immunol
Main Authors: Sheng, Zizhang, Schramm, Chaim A., Kong, Rui, Mullikin, James C., Mascola, John R., Kwong, Peter D., Shapiro, Lawrence
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424261/
https://ncbi.nlm.nih.gov/pubmed/28539926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00537
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