Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation

Somatic hypermutation (SHM) plays a critical role in the maturation of antibodies, optimizing recognition initiated by recombination of V(D)J genes. Previous studies have shown that the propensity to mutate is modulated by the context of surrounding nucleotides and that SHM machinery generates biase...

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Библиографические подробности
Опубликовано в: :Front Immunol
Главные авторы: Sheng, Zizhang, Schramm, Chaim A., Kong, Rui, Mullikin, James C., Mascola, John R., Kwong, Peter D., Shapiro, Lawrence
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2017
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424261/
https://ncbi.nlm.nih.gov/pubmed/28539926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00537
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