Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation

Somatic hypermutation (SHM) plays a critical role in the maturation of antibodies, optimizing recognition initiated by recombination of V(D)J genes. Previous studies have shown that the propensity to mutate is modulated by the context of surrounding nucleotides and that SHM machinery generates biase...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Immunol
Egile Nagusiak: Sheng, Zizhang, Schramm, Chaim A., Kong, Rui, Mullikin, James C., Mascola, John R., Kwong, Peter D., Shapiro, Lawrence
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2017
Gaiak:
Immunology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424261/
https://ncbi.nlm.nih.gov/pubmed/28539926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00537
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