Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment

While intron retention (IR) is considered a widely conserved and distinct mechanism of gene expression control, its regulation is poorly understood. Here we show that DNA methylation directly regulates IR. We also find reduced occupancy of MeCP2 near the splice junctions of retained introns, mirrori...

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Publicado en:Nat Commun
Autores principales: Wong, Justin J. -L., Gao, Dadi, Nguyen, Trung V., Kwok, Chau-To, van Geldermalsen, Michelle, Middleton, Rob, Pinello, Natalia, Thoeng, Annora, Nagarajah, Rajini, Holst, Jeff, Ritchie, William, Rasko, John E. J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424149/
https://ncbi.nlm.nih.gov/pubmed/28480880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15134
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