Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment

While intron retention (IR) is considered a widely conserved and distinct mechanism of gene expression control, its regulation is poorly understood. Here we show that DNA methylation directly regulates IR. We also find reduced occupancy of MeCP2 near the splice junctions of retained introns, mirrori...

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Publicat a:Nat Commun
Autors principals: Wong, Justin J. -L., Gao, Dadi, Nguyen, Trung V., Kwok, Chau-To, van Geldermalsen, Michelle, Middleton, Rob, Pinello, Natalia, Thoeng, Annora, Nagarajah, Rajini, Holst, Jeff, Ritchie, William, Rasko, John E. J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424149/
https://ncbi.nlm.nih.gov/pubmed/28480880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15134
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