Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

The combination of Cas9, guide RNA and repair template DNA can induce precise gene editing and the correction of genetic diseases in adult mammals. However, clinical implementation of this technology requires safe and effective delivery of all of these components into the nuclei of the target tissue...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Yin, Hao, Song, Chun-Qing, Dorkin, Joseph R, Zhu, Lihua J, Li, Yingxiang, Wu, Qiongqiong, Park, Angela, Yang, Junghoon, Suresh, Sneha, Bizhanova, Aizhan, Gupta, Ankit, Bolukbasi, Mehmet F, Walsh, Stephen, Bogorad, Roman L, Gao, Guangping, Weng, Zhiping, Dong, Yizhou, Koteliansky, Victor, Wolfe, Scot A, Langer, Robert, Xue, Wen, Anderson, Daniel G
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423356/
https://ncbi.nlm.nih.gov/pubmed/26829318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3471
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