Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition

Mutations in TP53 gene play a pivotal role in tumorigenesis and cancer development. Here, we report that gain‐of‐function mutant p53 proteins inhibit the autophagic pathway favoring antiapoptotic effects as well as proliferation of pancreas and breast cancer cells. We found that mutant p53 significa...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Oncol
Auteurs principaux: Cordani, Marco, Oppici, Elisa, Dando, Ilaria, Butturini, Elena, Dalla Pozza, Elisa, Nadal-Serrano, Mercedes, Oliver, Jordi, Roca, Pilar, Mariotto, Sofia, Cellini, Barbara, Blandino, Giovanni, Palmieri, Marta, Di Agostino, Silvia, Donadelli, Massimo
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2016
Sujets:
Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423176/
https://ncbi.nlm.nih.gov/pubmed/27118659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2016.04.001
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