Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition

Mutations in TP53 gene play a pivotal role in tumorigenesis and cancer development. Here, we report that gain‐of‐function mutant p53 proteins inhibit the autophagic pathway favoring antiapoptotic effects as well as proliferation of pancreas and breast cancer cells. We found that mutant p53 significa...

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Bibliografske podrobnosti
izdano v:Mol Oncol
Main Authors: Cordani, Marco, Oppici, Elisa, Dando, Ilaria, Butturini, Elena, Dalla Pozza, Elisa, Nadal-Serrano, Mercedes, Oliver, Jordi, Roca, Pilar, Mariotto, Sofia, Cellini, Barbara, Blandino, Giovanni, Palmieri, Marta, Di Agostino, Silvia, Donadelli, Massimo
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423176/
https://ncbi.nlm.nih.gov/pubmed/27118659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2016.04.001
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