Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O(2ˉ)· production in cancer cells

BACKGROUND: The TP53 tumor suppressor gene is the most frequently altered gene in tumors and mutant p53 gain-of-function isoforms actively promote cancer malignancy. METHODS: A panel of wild-type and mutant p53 cancer cell lines of different tissues, including pancreas, breast, skin, and lung were u...

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Publicado no:Br J Cancer
Main Authors: Cordani, Marco, Butera, Giovanna, Dando, Ilaria, Torrens-Mas, Margalida, Butturini, Elena, Pacchiana, Raffaella, Oppici, Elisa, Cavallini, Chiara, Gasperini, Sara, Tamassia, Nicola, Nadal-Serrano, Mercedes, Coan, Michela, Rossi, Davide, Gaidano, Gianluca, Caraglia, Michele, Mariotto, Sofia, Spizzo, Riccardo, Roca, Pilar, Oliver, Jordi, Scupoli, Maria Teresa, Donadelli, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203762/
https://ncbi.nlm.nih.gov/pubmed/30318520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0288-2
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