AGR2 oncoprotein inhibits p38 MAPK and p53 activation through a DUSP10‐mediated regulatory pathway

The tumor suppressor p53 plays a key role in malignant transformation and tumor development. However, the frequency of p53 mutations within individual types of cancer is different, suggesting the existence of other mechanisms attenuating p53 tumor suppressor activity. Changes in upstream regulators...

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Détails bibliographiques
Publié dans:Mol Oncol
Auteurs principaux: Hrstka, Roman, Bouchalova, Pavla, Michalova, Eva, Matoulkova, Eva, Muller, Petr, Coates, Philip J., Vojtesek, Borivoj
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2015
Sujets:
Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423154/
https://ncbi.nlm.nih.gov/pubmed/26733232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.12.003
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