AGR2 oncoprotein inhibits p38 MAPK and p53 activation through a DUSP10‐mediated regulatory pathway

The tumor suppressor p53 plays a key role in malignant transformation and tumor development. However, the frequency of p53 mutations within individual types of cancer is different, suggesting the existence of other mechanisms attenuating p53 tumor suppressor activity. Changes in upstream regulators...

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Pubblicato in:Mol Oncol
Autori principali: Hrstka, Roman, Bouchalova, Pavla, Michalova, Eva, Matoulkova, Eva, Muller, Petr, Coates, Philip J., Vojtesek, Borivoj
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2015
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423154/
https://ncbi.nlm.nih.gov/pubmed/26733232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.12.003
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