Kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer

Acquired resistance to CDK4/6 small molecule inhibitors in breast cancer arises through mechanisms that are yet uncharacterized. In this study, we used a kinome-wide siRNA screen to identify kinases which when downregulated yields sensitivity to the CDK4/6 inhibitor ribociclib. In this manner, we id...

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Udgivet i:Cancer Res
Main Authors: Jansen, Valerie M., Bhola, Neil E., Bauer, Joshua A., Formisano, Luigi, Lee, Kyung-min, Hutchinson, Katherine E., Witkiewicz, Agnieszka K., Moore, Preston D., Estrada, Mónica Valéria, Sánchez, Violeta, Ericsson, Paula G., Sanders, Melinda E., Pohlmann, Paula R., Pishvaian, Michael J., Riddle, David A., Dugger, Teresa C., Wei, Wenyi, Knudsen, Erik S., Arteaga, Carlos L.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421398/
https://ncbi.nlm.nih.gov/pubmed/28249908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2653
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