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In vivo instability of platensimycin and platencin: Synthesis and biological evaluation of urea- and carbamate-platensimycin
Platensimycin (PTM) and platencin (PTN), two natural products and promising drug leads that target bacterial and mammalian fatty acid synthases, are known to have unfavorable pharmacokinetic properties. It is not clear, however, what the metabolic fates of PTM and PTN are and no efforts have been re...
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| Опубликовано в: : | Bioorg Med Chem |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5421316/ https://ncbi.nlm.nih.gov/pubmed/28237556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.02.028 |
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