Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10

Targeted inhibition of Rho-associated kinase (ROCK)2 downregulates the proinflammatory T cell response while increasing the regulatory arm of the immune response in animals models of autoimmunity and Th17-skewing human cell culture in vitro. In this study, we report that oral administration of a sel...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Zanin-Zhorov, Alexandra, Weiss, Jonathan M., Trzeciak, Alissa, Chen, Wei, Zhang, Jingya, Nyuydzefe, Melanie S., Arencibia, Carmen, Polimera, Seetharam, Schueller, Olivier, Fuentes-Duculan, Judilyn, Bonifacio, Kathleen M., Kunjravia, Norma, Cueto, Inna, Soung, Jennifer, Fleischmann, Roy M., Kivitz, Alan, Lebwohl, Mark, Nunez, Margarita, Woodson, Johnnie, Smith, Shondra L., West, Robert F., Berger, Mark, Krueger, James G., Ryan, John L., Waksal, Samuel D.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2017
Assuntos:
Cutting Edge
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421306/
https://ncbi.nlm.nih.gov/pubmed/28389592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1602142
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