Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10

Targeted inhibition of Rho-associated kinase (ROCK)2 downregulates the proinflammatory T cell response while increasing the regulatory arm of the immune response in animals models of autoimmunity and Th17-skewing human cell culture in vitro. In this study, we report that oral administration of a sel...

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Vydáno v:J Immunol
Hlavní autoři: Zanin-Zhorov, Alexandra, Weiss, Jonathan M., Trzeciak, Alissa, Chen, Wei, Zhang, Jingya, Nyuydzefe, Melanie S., Arencibia, Carmen, Polimera, Seetharam, Schueller, Olivier, Fuentes-Duculan, Judilyn, Bonifacio, Kathleen M., Kunjravia, Norma, Cueto, Inna, Soung, Jennifer, Fleischmann, Roy M., Kivitz, Alan, Lebwohl, Mark, Nunez, Margarita, Woodson, Johnnie, Smith, Shondra L., West, Robert F., Berger, Mark, Krueger, James G., Ryan, John L., Waksal, Samuel D.
Médium: Artigo
Jazyk:Inglês
Vydáno: AAI 2017
Témata:
Cutting Edge
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421306/
https://ncbi.nlm.nih.gov/pubmed/28389592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1602142
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