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Dnase1L3 Regulates Inflammasome-Dependent Cytokine Secretion
Pediatric-onset systemic lupus erythematosus arises in humans and mice lacking the endonuclease Dnase1L3. When Dnase1L3 is absent, DNA from circulating apoptotic bodies is not cleared, leading to anti-DNA antibody production. Compared to early anti-DNA and anti-chromatin responses, other autoantibod...
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| Publicado no: | Front Immunol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5420570/ https://ncbi.nlm.nih.gov/pubmed/28533778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00522 |
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