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Reduction of Streptolysin O (SLO) Pore-Forming Activity Enhances Inflammasome Activation

Pore-forming toxins are utilized by bacterial and mammalian cells to exert pathogenic effects and induce cell lysis. In addition to rapid plasma membrane repair, macrophages respond to pore-forming toxins through activation of the NLRP3 inflammasome, leading to IL-1β secretion and pyroptosis. The st...

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Detalhes bibliográficos
Main Authors: Keyel, Peter A., Roth, Robyn, Yokoyama, Wayne M., Heuser, John E., Salter, Russell D.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717772/
https://ncbi.nlm.nih.gov/pubmed/23744055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins5061105
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