Genome editing in hPSCs reveals GATA6 haploinsufficiency and a modifying genetic interaction with GATA4 in human pancreatic development

Human disease phenotypes associated with haploinsufficient gene requirements are often not recapitulated well in animal models. Here, we have investigated the association between human GATA6 haploinsufficiency and a wide-range of clinical phenotypes that include neonatal and adult-onset diabetes usi...

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Bibliografiska uppgifter
I publikationen:Cell Stem Cell
Huvudupphovsmän: Shi, Zhong-Dong, Lee, Kihyun, Yang, Dapeng, Amin, Sadaf, Verma, Nipun, Li, Qing V., Zhu, Zengrong, Soh, Chew-Li, Kumar, Ritu, Evans, Todd, Chen, Shuibing, Huangfu, Danwei
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419850/
https://ncbi.nlm.nih.gov/pubmed/28196600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.01.001
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