Genome editing in hPSCs reveals GATA6 haploinsufficiency and a modifying genetic interaction with GATA4 in human pancreatic development

Human disease phenotypes associated with haploinsufficient gene requirements are often not recapitulated well in animal models. Here, we have investigated the association between human GATA6 haploinsufficiency and a wide-range of clinical phenotypes that include neonatal and adult-onset diabetes usi...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Cell Stem Cell
Päätekijät: Shi, Zhong-Dong, Lee, Kihyun, Yang, Dapeng, Amin, Sadaf, Verma, Nipun, Li, Qing V., Zhu, Zengrong, Soh, Chew-Li, Kumar, Ritu, Evans, Todd, Chen, Shuibing, Huangfu, Danwei
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419850/
https://ncbi.nlm.nih.gov/pubmed/28196600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.01.001
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