Genome editing of lineage determinants in human pluripotent stem cells reveals mechanisms of pancreatic development and diabetes

Directed differentiation of human pluripotent stem cells (hPSCs) into somatic counterparts is a valuable tool for studying disease. However, examination of developmental mechanisms in hPSCs remains challenging given complex multi-factorial actions at different stages. Here, we used TALEN and CRISPR-...

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Udgivet i:Cell Stem Cell
Main Authors: Zhu, Zengrong, Li, Qing V., Lee, Kihyun, Rosen, Bess P., González, Federico, Soh, Chew-Li, Huangfu, Danwei
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4892994/
https://ncbi.nlm.nih.gov/pubmed/27133796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.03.015
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