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Genome editing of lineage determinants in human pluripotent stem cells reveals mechanisms of pancreatic development and diabetes
Directed differentiation of human pluripotent stem cells (hPSCs) into somatic counterparts is a valuable tool for studying disease. However, examination of developmental mechanisms in hPSCs remains challenging given complex multi-factorial actions at different stages. Here, we used TALEN and CRISPR-...
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| Publicado no: | Cell Stem Cell |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4892994/ https://ncbi.nlm.nih.gov/pubmed/27133796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.03.015 |
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