Rapid assessment of oxidation via middle-down LCMS correlates with methionine side-chain solvent-accessible surface area for 121 clinical stage monoclonal antibodies

Susceptibility of methionine to oxidation is an important concern for chemical stability during the development of a monoclonal antibody (mAb) therapeutic. To minimize downstream risks, leading candidates are usually screened under forced oxidation conditions to identify oxidation-labile molecules....

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Pubblicato in:MAbs
Autori principali: Yang, Rong, Jain, Tushar, Lynaugh, Heather, Nobrega, R. Paul, Lu, Xiaojun, Boland, Todd, Burnina, Irina, Sun, Tingwan, Caffry, Isabelle, Brown, Michael, Zhi, Xiaoyong, Lilov, Asparouh, Xu, Yingda
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2017
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Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419077/
https://ncbi.nlm.nih.gov/pubmed/28281887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1290753
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