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How do messenger RNA splicing alterations drive myelodysplasia?

Mutations in RNA splicing factors are the single most common class of genetic alterations in myelodysplastic syndrome (MDS) patients. Although much has been learned about how these mutations affect splicing at a global- and transcript-specific level, critical questions about the role of these mutati...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Joshi, Poorval, Halene, Stephanie, Abdel-Wahab, Omar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418633/
https://ncbi.nlm.nih.gov/pubmed/28348147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-02-692715
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