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How do messenger RNA splicing alterations drive myelodysplasia?

Mutations in RNA splicing factors are the single most common class of genetic alterations in myelodysplastic syndrome (MDS) patients. Although much has been learned about how these mutations affect splicing at a global- and transcript-specific level, critical questions about the role of these mutati...

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Pubblicato in:Blood
Autori principali: Joshi, Poorval, Halene, Stephanie, Abdel-Wahab, Omar
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418633/
https://ncbi.nlm.nih.gov/pubmed/28348147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-02-692715
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