Prognostic and predictive value of circulating tumor cells and CXCR4 expression as biomarkers for a CXCR4 peptide antagonist in combination with carboplatin-etoposide in small cell lung cancer: exploratory analysis of a phase II study

Background Circulating tumor cells (CTCs) and chemokine (C-X-C motif) receptor 4 (CXCR4) expression in CTCs and tumor tissue were evaluated as prognostic or predictive markers of CXCR4 peptide antagonist LY2510924 plus carboplatin-etoposide (CE) versus CE in extensive-stage disease small cell lung c...

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Podrobná bibliografie
Vydáno v:Invest New Drugs
Hlavní autoři: Salgia, Ravi, Weaver, R. Waide, McCleod, Michael, Stille, John R., Yan, S. Betty, Roberson, Stephanie, Polzer, John, Flynt, Amy, Raddad, Eyas, Peek, Victoria L., Wijayawardana, Sameera R., Um, Suzane L., Gross, Steve, Connelly, Mark C., Morano, Carrie, Repollet, Madeline, Sanders, Renouard, Baeten, Kurt, D’Haese, David, Spigel, David R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2017
Témata:
Phase II Studies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418321/
https://ncbi.nlm.nih.gov/pubmed/28299514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-017-0446-z
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