Prognostic and predictive value of circulating tumor cells and CXCR4 expression as biomarkers for a CXCR4 peptide antagonist in combination with carboplatin-etoposide in small cell lung cancer: exploratory analysis of a phase II study

Background Circulating tumor cells (CTCs) and chemokine (C-X-C motif) receptor 4 (CXCR4) expression in CTCs and tumor tissue were evaluated as prognostic or predictive markers of CXCR4 peptide antagonist LY2510924 plus carboplatin-etoposide (CE) versus CE in extensive-stage disease small cell lung c...

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Detalles Bibliográficos
Publicado en:Invest New Drugs
Main Authors: Salgia, Ravi, Weaver, R. Waide, McCleod, Michael, Stille, John R., Yan, S. Betty, Roberson, Stephanie, Polzer, John, Flynt, Amy, Raddad, Eyas, Peek, Victoria L., Wijayawardana, Sameera R., Um, Suzane L., Gross, Steve, Connelly, Mark C., Morano, Carrie, Repollet, Madeline, Sanders, Renouard, Baeten, Kurt, D’Haese, David, Spigel, David R.
Formato: Artigo
Idioma:Inglês
Publicado: Springer US 2017
Assuntos:
Phase II Studies
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418321/
https://ncbi.nlm.nih.gov/pubmed/28299514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-017-0446-z
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