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Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2‐independent mechanism
Senescent cells contribute to age‐related pathology and loss of function, and their selective removal improves physiological function and extends longevity. Rapamycin, an inhibitor of mTOR, inhibits cell senescence in vitro and increases longevity in several species. Nrf2 levels have been shown to d...
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| Publicado no: | Aging Cell |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5418203/ https://ncbi.nlm.nih.gov/pubmed/28371119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12587 |
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