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Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2‐independent mechanism
Senescent cells contribute to age‐related pathology and loss of function, and their selective removal improves physiological function and extends longevity. Rapamycin, an inhibitor of mTOR, inhibits cell senescence in vitro and increases longevity in several species. Nrf2 levels have been shown to d...
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| Pubblicato in: | Aging Cell |
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| Autori principali: | , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5418203/ https://ncbi.nlm.nih.gov/pubmed/28371119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12587 |
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