Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic β-cells

Glucose metabolism promotes insulin secretion in β-cells via metabolic coupling factors that are incompletely defined. Moreover, chronically elevated glucose causes β-cell dysfunction, but little is known about how cells handle excess fuels to avoid toxicity. Here we sought to determine which among...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Mugabo, Yves, Zhao, Shangang, Lamontagne, Julien, Al-Mass, Anfal, Peyot, Marie-Line, Corkey, Barbara E., Joly, Erik, Madiraju, S. R. Murthy, Prentki, Marc
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418042/
https://ncbi.nlm.nih.gov/pubmed/28280244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.763060
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