Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons

AMP-activated kinase (AMPK) is a key player in energy sensing and metabolic reprogramming under cellular energy restriction. Several studies have linked impaired AMPK function to peripheral metabolic diseases such as diabetes. However, the impact of neurological disorders, such as Alzheimer disease...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Seixas da Silva, Gisele S., Melo, Helen M., Lourenco, Mychael V., Lyra e Silva, Natalia M., de Carvalho, Marcelo B., Alves-Leon, Soniza V., de Souza, Jorge M., Klein, William L., da-Silva, Wagner S., Ferreira, Sergio T., De Felice, Fernanda G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Neurobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418041/
https://ncbi.nlm.nih.gov/pubmed/28302722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753525
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