Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons

AMP-activated kinase (AMPK) is a key player in energy sensing and metabolic reprogramming under cellular energy restriction. Several studies have linked impaired AMPK function to peripheral metabolic diseases such as diabetes. However, the impact of neurological disorders, such as Alzheimer disease...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Seixas da Silva, Gisele S., Melo, Helen M., Lourenco, Mychael V., Lyra e Silva, Natalia M., de Carvalho, Marcelo B., Alves-Leon, Soniza V., de Souza, Jorge M., Klein, William L., da-Silva, Wagner S., Ferreira, Sergio T., De Felice, Fernanda G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2017
Soggetti:
Neurobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418041/
https://ncbi.nlm.nih.gov/pubmed/28302722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753525
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