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Amyloid-β Triggers the Release of Neuronal Hexokinase 1 from Mitochondria
Brain accumulation of the amyloid-β peptide (Aβ) and oxidative stress underlie neuronal dysfunction and memory loss in Alzheimer's disease (AD). Hexokinase (HK), a key glycolytic enzyme, plays important pro-survival roles, reducing mitochondrial reactive oxygen species (ROS) generation and prev...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3002973/ https://ncbi.nlm.nih.gov/pubmed/21179577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015230 |
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