Hexokinase II–derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells

Overexpression of mitochondria-bound hexokinase II (HKII) in cancer cells plays an important role in their metabolic reprogramming and protects them against apoptosis, thereby facilitating their growth and proliferation. Here, we show that covalently coupling a peptide corresponding to the mitochond...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:FASEB J
Hlavní autoři: Woldetsadik, Abiy D., Vogel, Maria C., Rabeh, Wael M., Magzoub, Mazin
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388548/
https://ncbi.nlm.nih.gov/pubmed/28183803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601173R
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky