Hexokinase II–derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells

Overexpression of mitochondria-bound hexokinase II (HKII) in cancer cells plays an important role in their metabolic reprogramming and protects them against apoptosis, thereby facilitating their growth and proliferation. Here, we show that covalently coupling a peptide corresponding to the mitochond...

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Udgivet i:FASEB J
Main Authors: Woldetsadik, Abiy D., Vogel, Maria C., Rabeh, Wael M., Magzoub, Mazin
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388548/
https://ncbi.nlm.nih.gov/pubmed/28183803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601173R
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