Hexokinase II–derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells

Overexpression of mitochondria-bound hexokinase II (HKII) in cancer cells plays an important role in their metabolic reprogramming and protects them against apoptosis, thereby facilitating their growth and proliferation. Here, we show that covalently coupling a peptide corresponding to the mitochond...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Woldetsadik, Abiy D., Vogel, Maria C., Rabeh, Wael M., Magzoub, Mazin
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388548/
https://ncbi.nlm.nih.gov/pubmed/28183803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601173R
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