Amyloid-β Triggers the Release of Neuronal Hexokinase 1 from Mitochondria

Brain accumulation of the amyloid-β peptide (Aβ) and oxidative stress underlie neuronal dysfunction and memory loss in Alzheimer's disease (AD). Hexokinase (HK), a key glycolytic enzyme, plays important pro-survival roles, reducing mitochondrial reactive oxygen species (ROS) generation and prev...

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Main Authors: Saraiva, Leonardo M., Seixas da Silva, Gisele S., Galina, Antonio, da-Silva, Wagner S., Klein, William L., Ferreira, Sérgio T., De Felice, Fernanda G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2010
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3002973/
https://ncbi.nlm.nih.gov/pubmed/21179577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015230
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