Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice

Brain accumulation of the amyloid-β protein (Aβ) and synapse loss are neuropathological hallmarks of Alzheimer disease (AD). Aβ oligomers (AβOs) are synaptotoxins that build up in the brains of patients and are thought to contribute to memory impairment in AD. Thus, identification of novel synaptic...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Brito-Moreira, Jordano, Lourenco, Mychael V., Oliveira, Mauricio M., Ribeiro, Felipe C., Ledo, José Henrique, Diniz, Luan P., Vital, Juliana F. S., Magdesian, Margaret H., Melo, Helen M., Barros-Aragão, Fernanda, de Souza, Jorge M., Alves-Leon, Soniza V., Gomes, Flavia C. A., Clarke, Julia R., Figueiredo, Cláudia P., De Felice, Fernanda G., Ferreira, Sergio T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2017
Aiheet:
Neurobiology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418035/
https://ncbi.nlm.nih.gov/pubmed/28283575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.761189
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