Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice

Brain accumulation of the amyloid-β protein (Aβ) and synapse loss are neuropathological hallmarks of Alzheimer disease (AD). Aβ oligomers (AβOs) are synaptotoxins that build up in the brains of patients and are thought to contribute to memory impairment in AD. Thus, identification of novel synaptic...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Biol Chem
मुख्य लेखकों: Brito-Moreira, Jordano, Lourenco, Mychael V., Oliveira, Mauricio M., Ribeiro, Felipe C., Ledo, José Henrique, Diniz, Luan P., Vital, Juliana F. S., Magdesian, Margaret H., Melo, Helen M., Barros-Aragão, Fernanda, de Souza, Jorge M., Alves-Leon, Soniza V., Gomes, Flavia C. A., Clarke, Julia R., Figueiredo, Cláudia P., De Felice, Fernanda G., Ferreira, Sergio T.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2017
विषय:
Neurobiology
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418035/
https://ncbi.nlm.nih.gov/pubmed/28283575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.761189
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