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Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation

Postsynaptic neuroligins are thought to perform essential functions in synapse validation and synaptic transmission by binding to, and dimerizing, presynaptic α- and β-neurexins. To test this hypothesis, we examined the functional effects of neuroligin-1 mutations that impair only α-neurexin binding...

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Detalhes bibliográficos
Main Authors: Ko, Jaewon, Zhang, Chen, Arac, Demet, Boucard, Antony A, Brunger, Axel T, Südhof, Thomas C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771087/
https://ncbi.nlm.nih.gov/pubmed/19730411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.249
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